About

What is CARES NG?

The Cumulative and Aggregate Risk Evaluation System Next Generation (CARES NG) Development Organization is a US 501(c)(6) not for profit business entity to develop and maintain the next generation of CARES™ (called CARES NG, or CARES Next Generation), a probabilistic software model which facilitates multi-source, multi-route aggregate (for individual chemicals) and cumulative (for multiple chemicals) exposure and risk assessments. The goal of the organization is to advance aggregate and cumulative exposure and risk modeling methods and capabilities for the benefit of the scientific, regulatory and public interest communities.  CARES NG will be available in the public domain. Accordingly, no member of the Organization shall have an ownership or proprietary interest in CARES NG.

What is the history of CARES?

CARES® (Cumulative and Aggregate Risk Evaluation System) was originally developed in 2001 as a population, calendar-based, probabilistic model for estimating aggregate and cumulative exposure and risk across multiple routes: food, water, and residential for pesticides. The model is undergoing significant upgrades to meet current and future needs:

  • Move from PC-based to cloud-based system for easier updates.
  • Streamline the assessment process.
  • Update consumption, residue monitoring, and behavioral databases.
  • Revise the residential SOP algorithms to reflect current EPA guidelines.
  • Enable minute by minute exposure estimates for all routes of exposure with results that can be exported to physiologically based pharmacokinetic (PBPK) models.

Create a flexible model that can accommodate low- to high-tier assessments.

The goal of this next generation of CARES (CARES NG) is to advance aggregate and cumulative exposure and risk modeling methods and capabilities for the benefit of the scientific, regulatory, and public interest communities. CARES NG will be available for public use.

How is CARES NG Organized?

Membership in the CARES NG Development Organization is open to any task force, joint venture or consortium of chemical producers or pesticide registrants or any individual chemical producer (including processor) or pesticide registrant who desires to support development of the next generation of CARES (CARES NG).  The following entities contributed financially towards the development of CARES NG and the representatives from these entities form the Board of Directors that governs the development of CARES NG.

BASF
Bayer
CAPHRA (Council for the Advancement of Pyrethroid Human Risk Assessment)
Dow AgroSciences
ORETF (Outdoor Residential Task Force)
PJV (Pyrethrin Joint Venture)
PWG (Pyrethroid Working Group)
REJV (Residential Exposure Joint Venture)
Syngenta
Valent

The Technical Advisory Group

The development of CARES NG is coordinated through its Technical Advisory Group (TAG). The TAG membership is open to technical experts from pesticide registrants, government agencies, members of academia, non-governmental organizations, and contract research organizations. No financial contribution is necessary to be a member of the TAG. The technical members representing the contributing entities advise their respective BOD representatives on development needs and decisions. The following are the members of the TAG:

BASF
Bayer
CAPHRA (Council for the Advancement of Pyrethroid Human Risk Assessment)
Dow AgroSciences
DuPont Crop Protection
Exponent Inc
George Mason University
Hamner Institute for Health Sciences
ORETF (Outdoor Residential Task Force)
PJV (Pyrethrin Joint Venture)
PWG (Pyrethroid Working Group)
REJV (Residential Exposure Joint Venture)
Syngenta
US-EPA
USDA-FSIS
Valent